Early in Ashworth's career, she played in the bands Sandpit and Scared of Horses. Her most recent band is Something for Kate, which she joined "sometime in 1997 or 1998, I can't remember," replacing Bassist Toby Ralph, a fill-in after Julian Carroll's departure. She frequently performs barefoot. In 2000, she was offered a place in Courtney Love's band, Hole, but declined.
Ashworth married her bandmate and Something for Kate frontman, Paul Dempsey, in 2006, and remains in this relationship as of 2013. Following the release of Dempsey's solo album Everything Is True, they relocated to New York City, USA, in 2010. They are parents to a son named Miller, born in 2011.
Since January 2008, Ashworth has written a monthly column for Jmag, the magazine of Australian radio station Triple J.
Ashworth has contributed artwork and photography to the releases of Something for Kate, and photos of New York City, United States (US) were used for the 2012 album Leave Your Soul to Science.