Shriram started Sherpalo, a venture capital firm that invests in promising new disruptive technologies, in January 2000.
He is a founding board member of Google and 7 (24/7 Customer). Shriram is also an investor in a global mobile ad network, InMobi, Search bid management tool Campanja and previously mKhoj. Shriram serves on the boards of Google, Paperless Post, Yubico and Zazzle. He owned 3.4 million shares of Google. As of September 2007, Shriram owned 1.7 million shares of Google.