Other notable roles include Mabel Nesbitt in Robert Altman's Oscar-winning Gosford Park and Charlotte Lucas in Joe Wright's 2005 version of Pride and Prejudice. In the autumn of 2007, she was seen in the BBC serial Cranford as Martha.
In 2010, Blakley played the role of Cynthia Lennon in the BBC television production of Lennon Naked, a drama based on the period in the life of John Lennon from the years 1964 to 1971. In 2013 she appeared in the premiere of the play Chimerica.