Bulgheroni joined his father's company in 1965 when he was 22 years old.
In 2010, Bulgheroni sold 50 percent of Bridas to Chinese state-run CNOOC Group, which was followed by the aqcuisition of Axion Energy Argentina in 2012, along with ExxonMobil’s crude-oil refineries and fuel and lubricants trading assets in Paraguay, Argentina and Uruguay.
According to Forbes, jointly with his brother Carlos, Bulgheroni has a net worth of $5.1 billion, as of January 2015. In 2016, his brother Carlos died of cancer at the age of 71.
As of 29 May 2017, Forbes estimates his net worth to be $3.5 billion, making him the 581st richest man in the world.